From the West End, take the Piccadilly line; estimate around 50 minutes to Terminal 5

https://holdencrae327.almoheet-travel.com/getting-to-heathrow-from-manchester-rail-coach-and-driving-compared-2

From the West End, take the Piccadilly line; estimate around 50 minutes to Terminal 5, and consider traveling off-peak for a more comfortable journey.